Tuesday, 19 March 2024

Fully Closed Looping - finally at my destination? Yes and No

There are fantastic group of people in the open source community who have developed AndroidAPS (a hybrid closed loop 'artificial' pancreas for Android).

This system can be set up to talk to your CGM (continuous Glucose monitor such as Libre or Dexcom) and use the BG data to control your BG semi-automatically.

The inputs required once you've configured the extensive settings and parameters are things like Carb declarations (how much you eat or plan to eat), planned exercise, and any of the more difficult patterns like pizza or pasta that need extended carbs.

To make this work really well, ultra-fast insulins (Fiasp or Lyumjev) make it much easier, as the time needed to pre-bolus is much reduced - a few or no minutes in advance of a meal and the insulin will be doing it stuff in 15 to 20 minutes or so.

Lyumjev (Humlaog with a vasal dilator ( Treprostinil ) added to speed up absorption) which is slightly faster than Fiasp (Novorapid with added nicotinamide/B3) - both of these make 'looping' easier to perform and less guess work for the end-user

This works really well, however still needs human-intervention to make it work.

There is a variant of AAPS written by Tim Street, called 'Boost' which uses the AAPS code, and adds a boost function to intercept UAMs (Un Announced Meals) and hit them harder with more insulin - so the end-user doesn't need to tell the HCL anything about whats being eaten (unless its pizza and pasta etc that need extended carbs, in my experience anyway)

Boost and be seen as a fully closed loop - I've been running this for 4 months now, and have only told it when I eat pizza (for 4-6 hours of extended carbs), otherwise its sorts itself out without me touching it.

There is a large amount of configuration required to ensure it gives enough insulin up front to avoid high BGs (in excess of 10mmol) for very long, and avoid a crashing low after a high BG, but once tweaked it really does replace the pancreas.

I'll update with more information in my next post - I have very nearly achieved a proper diet without me over bolusing or waking up in either high or low

Not quite perfect, but a step int he right direction and much better than we could ever achieve without the open-source community working to innovate and drive the pharmaceutical companies to develop faster and harder to improve our lives now, not in 15 years.

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